Fight Hypertension

If Volume overload heart like high blood pressure, it will cause the heart to enlarge and eventually it will stop pumping blood through heart failure. This disaster is a gene that RGS2 (Regulator of G-protein signaling-2), which functions to protect the heart from the failure. To prove the role of Viagra (sildanefil citrate) in protecting the heart from the harmful effects of high blood pressure was, by the mice with high blood pressure. These mice were divided into two groups, one those who have not RGS2 and the other with the RGS2, protective gene for the heart that prevents the heart from hypertrophy.

Both groups were induced with high blood pressure, and the mice without the gene RGS2 had over 90% increase in the weight of the heart and about half of the mice in this group died during the experiment. The study also showed that the mice that do not have RSG2 gene had no effect on heart sildanefil.

The experiments to study the impact of RSG2 to prevent heart enlargement have been about three years now and recent experiments focus to the combined effects of sildanefil and RSG2 at preventing heart enlargement.

The establishment of the fact that these RSG2 research on the genes in the heart that prevents its hypertrophy, the scientists can develop better therapies including ARB or sildanefil to prevent people from, in heart failure.

Currently doctors use the inhibitor-ARB and the ACE inhibitors block the Gq signals, because these drugs block the effects of Gq signals, they can relax and break the binding effect that causes increased blood pressure.

The researchers noted that pulmonary hypertension of the right ventricle of the heart and leads to the hypertrophy of the heart muscles. They found that the phosphodiesterase-5 is in the heart muscles of the right ventricle and sildanefil works to block, and the capacity of the muscles in the right ventricle in hypertrophic heart.

Sun sildanefil not only prevents pulmonary hypertension, but also improves the ability of the pumps have the right heart pumps blood that the left atrium, from where the blood is pumped into the left ventricle and then into the arterial tree.

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